{"product_id":"aicar-100mg","title":"Aicar 100mg","description":"\u003c!-- Improved AICAR 50mg Product Page Content for Ivarah Labs --\u003e\n\u003cdiv class=\"product-description\"\u003e\n  \u003ch1\u003eIvarah Labs AICAR 50mg – Research-Grade AMPK Activator\u003c\/h1\u003e\n \n  \u003cp\u003e\u003cstrong\u003eResearch Compound Overview\u003c\/strong\u003e\u003cbr\u003e\n  AICAR (5-Aminoimidazole-4-carboxamide ribonucleoside, also known as Acadesine) is a synthetic nucleoside analog widely used in laboratory research as a pharmacological tool to activate AMP-activated protein kinase (AMPK). It is cell-permeable and serves as a valuable probe for metabolic regulation, signaling pathways, and biochemical processes.\n  \u003c\/p\u003e\n\n  \u003ch2\u003eProduct Specifications\u003c\/h2\u003e\n  \u003ctable style=\"width:100%; border-collapse:collapse; margin:20px 0;\"\u003e\n    \u003cthead\u003e\n      \u003ctr style=\"background:#f0f4f8;\"\u003e\n        \u003cth style=\"padding:12px; border:1px solid #ddd; text-align:left;\"\u003eParameter\u003c\/th\u003e\n        \u003cth style=\"padding:12px; border:1px solid #ddd; text-align:left;\"\u003eSpecification\u003c\/th\u003e\n      \u003c\/tr\u003e\n    \u003c\/thead\u003e\n    \u003ctbody\u003e\n      \u003ctr\u003e\n        \u003ctd style=\"padding:12px; border:1px solid #ddd;\"\u003eIngredient\u003c\/td\u003e\n        \u003ctd style=\"padding:12px; border:1px solid #ddd;\"\u003eAICAR (5-Aminoimidazole-4-carboxamide ribonucleoside)\u003c\/td\u003e\n      \u003c\/tr\u003e\n      \u003ctr\u003e\n        \u003ctd style=\"padding:12px; border:1px solid #ddd;\"\u003eAmount per Vial\u003c\/td\u003e\n        \u003ctd style=\"padding:12px; border:1px solid #ddd;\"\u003e50 mg\u003c\/td\u003e\n      \u003c\/tr\u003e\n      \u003ctr\u003e\n        \u003ctd style=\"padding:12px; border:1px solid #ddd;\"\u003eMolecular Formula\u003c\/td\u003e\n        \u003ctd style=\"padding:12px; border:1px solid #ddd;\"\u003eC₉H₁₄N₄O₅\u003c\/td\u003e\n      \u003c\/tr\u003e\n      \u003ctr\u003e\n        \u003ctd style=\"padding:12px; border:1px solid #ddd;\"\u003eMolecular Weight\u003c\/td\u003e\n        \u003ctd style=\"padding:12px; border:1px solid #ddd;\"\u003e338.23 g\/mol\u003c\/td\u003e\n      \u003c\/tr\u003e\n      \u003ctr\u003e\n        \u003ctd style=\"padding:12px; border:1px solid #ddd;\"\u003eFormat\u003c\/td\u003e\n        \u003ctd style=\"padding:12px; border:1px solid #ddd;\"\u003eLyophilized powder in sterile research vial\u003c\/td\u003e\n      \u003c\/tr\u003e\n      \u003ctr\u003e\n        \u003ctd style=\"padding:12px; border:1px solid #ddd;\"\u003ePurity\u003c\/td\u003e\n        \u003ctd style=\"padding:12px; border:1px solid #ddd;\"\u003e≥98–99% (third-party verified)\u003c\/td\u003e\n      \u003c\/tr\u003e\n      \u003ctr\u003e\n        \u003ctd style=\"padding:12px; border:1px solid #ddd;\"\u003eAppearance\u003c\/td\u003e\n        \u003ctd style=\"padding:12px; border:1px solid #ddd;\"\u003eWhite to off-white powder\u003c\/td\u003e\n      \u003c\/tr\u003e\n      \u003ctr\u003e\n        \u003ctd style=\"padding:12px; border:1px solid #ddd;\"\u003eIntended Use\u003c\/td\u003e\n        \u003ctd style=\"padding:12px; border:1px solid #ddd;\"\u003eLaboratory research and analytical applications only\u003c\/td\u003e\n      \u003c\/tr\u003e\n    \u003c\/tbody\u003e\n  \u003c\/table\u003e\n \n  \u003c!-- Prominent COA Box --\u003e\n  \u003cdiv style=\"background:#f0f8f0; padding:20px; border-left:5px solid #28a745; margin:25px 0; border-radius:4px;\"\u003e\n    \u003cstrong\u003eBatch-Specific COA Available\u003c\/strong\u003e\u003cbr\u003e\n    Independent lab results include HPLC purity (≥98–99%), LC-MS confirmation, endotoxin, and solubility data.\u003cbr\u003e\n    \u003ca href=\"#\" style=\"color:#28a745; font-weight:bold; text-decoration:underline;\"\u003e→ View Current Batch COA (PDF)\u003c\/a\u003e\u003cbr\u003e\n    \u003csmall\u003eFull traceability. Public COA library coming soon.\u003c\/small\u003e\n  \u003c\/div\u003e\n\n  \u003ch2\u003eAMPK Mechanism of Action\u003c\/h2\u003e\n  \u003cp\u003e\n    AMP-activated protein kinase (AMPK) is a heterotrimeric serine\/threonine kinase complex (α catalytic, β and γ regulatory subunits) that serves as the cell’s primary energy sensor. Full activation typically requires phosphorylation at Thr172 on the α subunit (primarily by LKB1) and allosteric regulation via the γ subunit.\n  \u003c\/p\u003e\n\n  \u003ch2\u003eAMPK Signaling Pathways\u003c\/h2\u003e\n  \u003cp\u003e\n    Once activated, AMPK shifts cellular metabolism from anabolic (energy-consuming) to catabolic (energy-producing) pathways to restore energy balance. It acts as a master regulator of metabolism under conditions of energy stress such as exercise, nutrient deprivation, or hypoxia.\n  \u003c\/p\u003e\n  \u003ch3\u003eKey Downstream Targets\u003c\/h3\u003e\n  \u003cul\u003e\n    \u003cli\u003e\n\u003cstrong\u003eACC (Acetyl-CoA Carboxylase)\u003c\/strong\u003e: Inhibits fatty acid synthesis and promotes β-oxidation.\u003c\/li\u003e\n    \u003cli\u003e\n\u003cstrong\u003emTORC1 pathway\u003c\/strong\u003e (via TSC2\/Raptor): Suppresses protein synthesis and cell growth.\u003c\/li\u003e\n    \u003cli\u003e\n\u003cstrong\u003eGLUT4 \u0026amp; PFK2\u003c\/strong\u003e: Enhances glucose uptake and glycolysis.\u003c\/li\u003e\n    \u003cli\u003e\n\u003cstrong\u003eULK1\u003c\/strong\u003e: Promotes autophagy and mitochondrial quality control.\u003c\/li\u003e\n    \u003cli\u003e\n\u003cstrong\u003eGlycogen Synthase\u003c\/strong\u003e: Inhibits glycogen synthesis.\u003c\/li\u003e\n    \u003cli\u003e\n\u003cstrong\u003ePGC-1α\u003c\/strong\u003e: Promotes mitochondrial biogenesis.\u003c\/li\u003e\n  \u003c\/ul\u003e\n\n  \u003ch2\u003eOther AMPK Activators in Research\u003c\/h2\u003e\n  \u003cp\u003e\n    Researchers often compare AICAR with other AMPK modulators:\n  \u003c\/p\u003e\n  \u003ch3\u003eA-769662 – Direct AMPK Activator\u003c\/h3\u003e\n  \u003cp\u003e\n    \u003cstrong\u003eA-769662\u003c\/strong\u003e is a potent, direct small-molecule AMPK activator (thienopyridone class) that binds at a distinct site from AMP\/AICAR. It shows strong preference for β1-containing AMPK complexes and does not raise cellular AMP levels.\n  \u003c\/p\u003e\n  \u003cul\u003e\n    \u003cli\u003e\n\u003cstrong\u003eKey Advantage\u003c\/strong\u003e: Higher selectivity and fewer off-target effects compared to indirect activators.\u003c\/li\u003e\n    \u003cli\u003e\n\u003cstrong\u003eCommon Use\u003c\/strong\u003e: Isoform-specific studies, liver metabolism research, and synergy experiments with AICAR.\u003c\/li\u003e\n    \u003cli\u003e\n\u003cstrong\u003eComparison with AICAR\u003c\/strong\u003e: While AICAR is an AMP mimetic (indirect), A-769662 directly activates AMPK, making it a complementary research tool.\u003c\/li\u003e\n  \u003c\/ul\u003e\n\n  \u003ch2\u003eScientific Background \u0026amp; Research Applications\u003c\/h2\u003e\n  \u003cp\u003e\n    AICAR is widely used in laboratory models to study cellular energy regulation, metabolic adaptation, and AMPK-related pathways.\n  \u003c\/p\u003e\n  \u003ch3\u003eKey Areas of Laboratory Investigation\u003c\/h3\u003e\n  \u003cul\u003e\n    \u003cli\u003eCellular energy homeostasis and glucose\/fatty acid metabolism\u003c\/li\u003e\n    \u003cli\u003eAutophagy and mitochondrial function\u003c\/li\u003e\n    \u003cli\u003eMuscle and tissue models (atrophy, regeneration)\u003c\/li\u003e\n    \u003cli\u003eMetabolic stress and hypoxia responses\u003c\/li\u003e\n  \u003c\/ul\u003e\n\n  \u003ch2\u003eSolubility \u0026amp; Reconstitution Instructions (Laboratory Best Practices)\u003c\/h2\u003e\n  \u003cul\u003e\n    \u003cli\u003e\n\u003cstrong\u003eSolubility Profile\u003c\/strong\u003e: AICAR is generally soluble in water and aqueous buffers (e.g., PBS). However, high-concentration stock solutions (\u0026gt;50–100 mM) may require gentle warming or sonication. Avoid exceeding solubility limits to prevent precipitation.\u003c\/li\u003e\n    \u003cli\u003e\n\u003cstrong\u003eRecommended Solvent\u003c\/strong\u003e: Sterile bacteriostatic water or research-grade PBS.\u003c\/li\u003e\n    \u003cli\u003e\n\u003cstrong\u003eProcedure\u003c\/strong\u003e:\n      \u003col\u003e\n        \u003cli\u003eBring sealed vial to room temperature.\u003c\/li\u003e\n        \u003cli\u003eAdd solvent slowly along the vial wall.\u003c\/li\u003e\n        \u003cli\u003eGently swirl or use bath sonication until fully dissolved; avoid vigorous shaking.\u003c\/li\u003e\n        \u003cli\u003eAliquot immediately.\u003c\/li\u003e\n      \u003c\/ol\u003e\n    \u003c\/li\u003e\n    \u003cli\u003e\n\u003cstrong\u003ePost-Reconstitution\u003c\/strong\u003e: Store aliquots at -20°C or -80°C to minimize freeze-thaw cycles.\u003c\/li\u003e\n  \u003c\/ul\u003e\n\n  \u003ch2\u003eHandling \u0026amp; Storage (Laboratory Best Practices)\u003c\/h2\u003e\n  \u003cul\u003e\n    \u003cli\u003e\n\u003cstrong\u003eLyophilized\u003c\/strong\u003e: -20°C or lower, protected from light and moisture.\u003c\/li\u003e\n    \u003cli\u003e\n\u003cstrong\u003eGeneral\u003c\/strong\u003e: Follow institutional protocols; protect from heat and temperature fluctuations.\u003c\/li\u003e\n  \u003c\/ul\u003e\n\n  \u003ch2\u003eQuality Assurance \u0026amp; Transparency\u003c\/h2\u003e\n  \u003cp\u003e\n    Every batch is third-party tested for identity, purity, and quality.\n  \u003c\/p\u003e\n \n  \u003c!-- Second COA Mention --\u003e\n  \u003cdiv style=\"background:#f0f8f0; padding:18px; border-left:4px solid #28a745; margin:20px 0; border-radius:4px;\"\u003e\n    \u003cstrong\u003eVerify Before Purchase\u003c\/strong\u003e\u003cbr\u003e\n    \u003ca href=\"#\" style=\"color:#28a745; font-weight:bold; text-decoration:underline;\"\u003e→ View Current Batch COA (PDF)\u003c\/a\u003e\u003cbr\u003e\n    \u003csmall\u003eIndependent HPLC, LC-MS, endotoxin, and solubility results for full transparency.\u003c\/small\u003e\n  \u003c\/div\u003e\n\n  \u003ch2\u003eWhy Researchers Choose Ivarah Labs\u003c\/h2\u003e\n  \u003cul\u003e\n    \u003cli\u003eIn-depth, reference-supported scientific context\u003c\/li\u003e\n    \u003cli\u003eTransparent batch-specific third-party COAs\u003c\/li\u003e\n    \u003cli\u003eHigh-purity, consistent research materials\u003c\/li\u003e\n    \u003cli\u003eFocus on supporting advanced laboratory investigations\u003c\/li\u003e\n  \u003c\/ul\u003e\n\n  \u003chr style=\"margin:40px 0 30px 0;\"\u003e\n\n  \u003c!-- Centered Research Use Only Section --\u003e\n  \u003cdiv style=\"text-align: center; max-width: 700px; margin: 0 auto;\"\u003e\n    \u003ch2 style=\"color: #d32f2f; margin-bottom: 12px;\"\u003eResearch Use Only\u003c\/h2\u003e\n    \u003cp style=\"color:#d32f2f; font-weight:bold; font-size: 16px; margin-bottom: 8px;\"\u003e\n      \u003cstrong\u003eFOR RESEARCH USE ONLY.\u003c\/strong\u003e NOT FOR HUMAN CONSUMPTION.\u003cbr\u003e\n      NOT FOR DIAGNOSTIC, THERAPEUTIC, OR MEDICAL USE.\n    \u003c\/p\u003e\n    \u003cp style=\"color: #555; line-height: 1.6;\"\u003e\n      Intended solely for laboratory research by qualified professionals. Purchasers must comply with all applicable laws and institutional guidelines.\n    \u003c\/p\u003e\n  \u003c\/div\u003e\n\n  \u003c!-- Hidden SEO Keywords --\u003e\n  \u003cdiv style=\"display:none;\"\u003e\n    AICAR research, AICAR 50mg, AMPK activator, A-769662, AMPK signaling pathways, Acadesine, metabolic research, high purity AICAR, Ivarah Labs\n  \u003c\/div\u003e\n\u003c\/div\u003e","brand":"Ivarah Labs","offers":[{"title":"Default Title","offer_id":58006562111791,"sku":"ACR50","price":98.57,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0987\/0311\/4543\/files\/Aicar50mg_4640e8b7-1c80-423e-b22f-397ac5f79a8b.png?v=1781137436","url":"https:\/\/ivarahlabs.com\/products\/aicar-100mg","provider":"Ivarah Labs","version":"1.0","type":"link"}