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Research-grade compound supplied by Ivarah Labs.
Ascorbyl Tetraisopalmitate (Lipo-C / THDA / VC-IP) is a stable, lipid-soluble tetraester of Vitamin C. It is highly valued in laboratory research for its oxidative stability, deep penetration, and controlled enzymatic conversion to bioactive ascorbic acid.
| Parameter | Specification |
|---|---|
| Active Ingredient | Ascorbyl Tetraisopalmitate (Lipo-C) |
| Amount per Vial | 10 mg |
| CAS Number | 183476-82-6 |
| Purity (HPLC) | 99.45% |
| Assay | 99.32% |
| Appearance | White to off-white lyophilized powder |
| Format | Lyophilized powder in sterile 5mL research vial |
| Intended Use | Laboratory research and analytical applications only |
Ascorbyl Tetraisopalmitate is primarily hydrolyzed by human carboxylesterases CES1 and CES2. CES1 shows higher affinity for substrates with large acyl groups (such as the palmitate chains in Lipo-C), while CES2 prefers substrates with smaller acyl groups but can also process larger esters. This differential specificity results in a gradual, multi-step hydrolysis that releases free ascorbic acid in a sustained manner.
Due to its highly lipophilic nature, Lipo-C integrates efficiently into liposomal bilayers. Optimal liposomal formulations often include:
Cholesterol increases the phase transition temperature (Tm) of the liposomal membrane, shifting it from a gel to liquid-crystalline phase, which enhances vesicle stability and reduces leakage of encapsulated compounds. This makes cholesterol-containing liposomes particularly suitable for delivering lipophilic Vitamin C derivatives like Lipo-C.
Several clinical studies have evaluated topical Ascorbyl Tetraisopalmitate:
| Derivative | Solubility | Stability | Penetration | Irritation | Conversion |
|---|---|---|---|---|---|
| Ascorbyl Tetraisopalmitate (Lipo-C) | Oil-soluble | Excellent | Excellent | Very Low | CES1 / CES2 |
| L-Ascorbic Acid | Water-soluble | Poor | Moderate | High | Direct |
| Sodium Ascorbyl Phosphate | Water-soluble | Good | Moderate | Low | Phosphatase |
Store at 2–8°C, protected from light and moisture.
Every batch is third-party tested (HPLC). Certificate of Analysis available for download above.
FOR RESEARCH USE ONLY.
NOT FOR HUMAN CONSUMPTION.
NOT FOR DIAGNOSTIC, THERAPEUTIC, OR MEDICAL USE.
This product is intended solely for laboratory research by qualified professionals in a controlled research environment.
FOR RESEARCH USE ONLY. NOT FOR HUMAN CONSUMPTION.
NOT FOR DIAGNOSTIC, THERAPEUTIC, OR MEDICAL USE.
This product is provided strictly for laboratory research conducted by qualified professionals. Customers acknowledge that it is intended solely for non-human, non-clinical research purposes. Research-grade compound supplied by Ivarah Labs.
NOT FOR HUMAN CONSUMPTION. These products are not intended to diagnose, treat, cure, or prevent any disease and are supplied exclusively for legitimate laboratory research.
Products offered by Ivarah Labs are intended solely for in-vitro laboratory research conducted by qualified professionals in controlled research environments.
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